The Swiss National Supercomputing Centre in collaboration with the HPC-AI Advisory Council and HPCXXL Board, will host the 10th annual Swiss Conference and bi-annual HPCXXL Winter Meeting in Lugano, Switzerland, from 1 – 4 April, 2019. The combined proceedings kick-off with the three day, open to all, annual Swiss Conference. This highly interactive forum draws leaders from private and public industry to learn from each other by openly sharing expertise and findings. The four day forum concludes with the HPCXXL User Group. This bi-annual, Board hosted, members and by invitation -only meeting is open to large-scale IBM and Lenovo system users, partners and affiliates.